| Item type |
紀要論文 / Departmental Bulletin Paper_02(1) |
| 公開日 |
2018-11-23 |
| タイトル |
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|
タイトル |
システム生物学のための統合解析シミュレータ WinBEST-KIT の開発 |
| その他のタイトル |
|
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その他のタイトル |
WinBEST-KIT: Integrated simulation environment for systems biology |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
主題 |
システム生物学 |
| キーワード |
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|
主題 |
代謝経路 |
| キーワード |
|
|
主題 |
生化学反応系解析シミュレータ |
| キーワード |
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|
主題 |
数理モデル |
| キーワード |
|
|
主題 |
確率微分方程式モデル |
| キーワード |
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主題 |
Euler-Maruyama法 |
| キーワード |
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主題 |
Systems biology |
| キーワード |
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主題 |
Metabolic pathways |
| キーワード |
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主題 |
Biochemical reaction simulator |
| キーワード |
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主題 |
Mathematical model |
| キーワード |
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主題 |
Stochastic fluctuation |
| キーワード |
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主題 |
Euler-Maruyama method |
| 著者 |
関口, 達也
セキグチ, タツヤ
Sekiguchi, Tatsuya
|
| 抄録 |
|
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内容記述タイプ |
Abstract |
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内容記述 |
Previously, I developed the biochemical reaction simulator called WinBEST-KIT (Biochemical Engineering System analyzing Tool-KIT, which runs under Microsoft Windows) for analyzing complicated biochemical reaction systems such as metabolic pathways. WinBEST-KIT provides an integrated simulation environment for experimental researchers in the field of systems biology. One of the most notable features of WinBEST-KIT is that users can very easily customize user-defined reaction step symbols in the graphical user interface. It realizes that users can use their original mathematical kinetic equations for representing unknown kinetic mechanisms as reaction steps in addition to the prepared standard (pre-installed) mathematical kinetic equations such as Michaelis-Menten equation. The problem we must be considered is, however, that the mathematical modeling for the dynamics of the large-scale biochemical reaction systems needs stochastic fluctuation for the several reaction steps. In this study, I developed a new version of WinBEST-KIT that enables users to include the stochastic fluctuation into the customized user-defined reaction step symbols. Therefore, it is possible to include simultaneously both the reaction step symbols in which involve with the stochastic fluctuation and the reaction step symbols in which involve the conventional deterministic reactions, at constructing the model of the biochemical reaction systems to be analyzed with WinBEST-KIT. |
| 書誌情報 |
発行日 2018-03-31
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| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1343-8867 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11225201 |
| 資源タイプ |
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内容記述タイプ |
Other |
|
内容記述 |
Thesis or Dissertation |
| 更新日 |
|
|
日付 |
2018-11-24 |
|
日付タイプ |
Created |
25〔研究論文〕システム生物学のための統合解析シミュレータWinBEST-KITの開発(P29-P36)（関口）.pdf (821.6 kB)
