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内容記述 |
Collagen is one of the major extracellular matrix proteins in mammals and fish. Its abundance is especially\nconcentrated in connective tissues, such as ears, tendons, ligaments, cartilage, and skin. Recently, collagen has\nbeen widely used as a biomaterial in artificial skin, suture thread, and artificial corneas and as a carrier vehicle for\ngene therapy in medical fields. We previously reported that extracted porcine auricular collagen (PAC) had\nexquisite viscoelasticity and promoted greater cell proliferation than skin-extracted collagen.\nIn this study, we demonstrated that auricular collagen inhibited water transpiration through in vivo and in vitro\nexperiments, and that PAC sheets retained water and maintained skin elasticity in mouse and human skin. In\nvitro, a PAC solution significantly inhibited water transpiration compared to only water or to a mixture of water\nwith 10% glycerol. In human trial participants, skin treatment with PAC sheets increased elasticity and obviously\nimproved the skin's texture. These results suggested that PAC had good effects on the water retention, texture, and\nelasticity of skin compared to other skin collagen and /or moisturizing ingredients such as glycerol. |